The Pride Grand Prix 2000 Opening Round was a mixed martial arts event held by the Pride Fighting Championships. It took place at the Tokyo Dome in Tokyo, Japan on January 30, 2000. The event began the Pride Openweight tournament of 2000.

Gary Goodridge vs. Osamu Kawahara
Goodridge defeated Tachihikari via submission (forearm choke) at 0:51 of round 1.
Kawahara fought under the name Tachihikari.

Ebenezer Fontes Braga vs. Akira Shoji
Shoji defeated Braga via unanimous decision.

Kazuyuki Fujita vs. Hans Nijman
Fujita defeated Nijman via submission (scarf hold) at 2:48 of round 1.

Guy Mezger vs. Kazushi Sakuraba
Sakuraba defeated Mezger via TKO (retirement) at 15:00 of round 1. Mezger forfeited the fight by leaving the ring after the bout was declared a draw and sent to an overtime round.

Mark Coleman vs. Masaaki Satake
Coleman defeated Satake via submission (neck crank) at 1:14 of round 1.

Alexander Otsuka vs. Igor Vovchanchyn
Vovchanchyn defeated Otsuka via unanimous decision.

Enson Inoue vs. Mark Kerr
Kerr defeated Inoue via unanimous decision.

Royce Gracie vs. Nobuhiko Takada
Gracie defeated Takada via unanimous decision.